{"id":15192,"date":"2024-09-17T09:13:48","date_gmt":"2024-09-17T07:13:48","guid":{"rendered":"https:\/\/dev.shimadzu-testing.com\/?p=15192"},"modified":"2025-02-05T11:37:36","modified_gmt":"2025-02-05T10:37:36","slug":"tensile-testing-of-cultured-epidermis","status":"publish","type":"post","link":"https:\/\/shimadzu-testing.com\/en\/know-how\/tensile-testing\/tensile-testing-of-cultured-epidermis\/","title":{"rendered":"Tensile Testing of Cultured Epidermis"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"15192\" class=\"elementor elementor-15192\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4e15197 e-flex e-con-boxed e-con e-parent\" data-id=\"4e15197\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a8c5eeb elementor-widget elementor-widget-text-editor\" data-id=\"a8c5eeb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><strong>Introduction<\/strong><\/h2>\nVarious research institutes and businesses have been developing regenerative medical products*1 in the recent years in order to facilitate the spread of regenerative medicine. Since quality control is crucial for regenerative medical products, various material[1][2] has been issued by the Pharmaceuticals and Medical Devices Agency (PMDA)\n\nTesting system EZ-LX\nLoad cell 10 N\nTest fixture Tensile test fixture for cultured epidermis\n\nTable 2 Specimen Information\n\nDimensions 50 mm \u00d7 100 mm\n\nwhich conducts reviews. Although the issued material calls for dynamic evaluations in addition to biological evaluations, they do not include a description of specific evaluation methods. Dynamic evaluation was conducted upon transplanting iPS cell-derived retinal pigment\n\nTypes\n\nThickness of less than 100 \u03bcm\nMilk membrane Cultured epidermis A Cultured epidermis B\n\nTable 3 Test Conditions\n\nepithelial cell sheets, but the evaluation method was no more than qualitative, consisting of only checks for damage at the time of graft preparation.[3] However, quantitative evaluations will likely be necessary for cell sheets[5] which require mechanical strength such as cultured skin sheets[4] and myocardial cell sheets. Furthermore, unlike the current regenerative medical products using autologous cells, it is possible that regenerative medical products using allogeneic cells[6], which are expected to become mainstream in the future, will be required to observe specification tests based on quantitative quality standards.\nIn this research, tensile tests were performed using cultured epidermis, which is a regenerative medical product, and milk membrane imitating cultured epidermis (collected from the surface of hot milk) as an example of a quantitative evaluation of a material&#8217;s mechanical properties.<br> <br>\n*1 Regenerative medical products are items created by processing human or animal cells for reconstructing, repairing, or forming body structures and functions or for treating or preventing diseases.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f4c2158 elementor-widget elementor-widget-text-editor\" data-id=\"f4c2158\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Measurement System<\/h2>\nTable 1 and Table 2 indicate the system composition and\ninformation of the specimens respectively. Fig. 1 shows a\ncultured epidermis specimen. The tests were performed\nusing milk membrane imitating cultured epidermis\n(dummy specimen) and two types of research-purpose\ncultured epidermis (A and B)*2 with differing firmness\nmade by using the same method as that for autologous\ncultured epidermis JACE\u00ae. The thickness of cultured\nepidermis specimens was less than 100 \u03bcm and the\nstructure of the specimens consisted of a few layers of\nepidermal cells. Specimens were flexible and kept moist\nby soaking in preservative solution. The specimens\ntherefore had to be mounted and measured quickly\nduring the tensile tests in order to maintain their\nmoistness. Fig. 2 is a picture of the test. Cylindrical\nsponges are used for the fixture. By wrapping a specimen\naround these sponges, specimens can be held during the\ntest without damaging them. Table 3 shows the test\nconditions. The test speed was set to a low speed within\nthe speed range in which specimens remain moist.\n<br> <br>\n*2 Provided by Japan Tissue Engineering Co., Ltd.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6b5fea1 e-grid e-con-full e-con e-child\" data-id=\"6b5fea1\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-443da9c elementor-widget elementor-widget-image\" data-id=\"443da9c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-1-system-composition.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"tensile-testing-of-cultured-epidermis-table-1-system-composition\" data-elementor-lightbox-description=\"Table 1 System Composition\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTUxODksInVybCI6Imh0dHBzOlwvXC9zaGltYWR6dS10ZXN0aW5nLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDlcL3RlbnNpbGUtdGVzdGluZy1vZi1jdWx0dXJlZC1lcGlkZXJtaXMtdGFibGUtMS1zeXN0ZW0tY29tcG9zaXRpb24uanBnIn0%3D\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"117\" src=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-1-system-composition-768x117.jpg\" class=\"attachment-medium_large size-medium_large wp-image-15189\" alt=\"Table 1 System Composition\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Table 1 System Composition<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28d07d7 elementor-widget elementor-widget-image\" data-id=\"28d07d7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-3-test-conditions.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"tensile-testing-of-cultured-epidermis-table-3-test-conditions\" data-elementor-lightbox-description=\"Table 3 Test Conditions\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTUxOTEsInVybCI6Imh0dHBzOlwvXC9zaGltYWR6dS10ZXN0aW5nLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDlcL3RlbnNpbGUtdGVzdGluZy1vZi1jdWx0dXJlZC1lcGlkZXJtaXMtdGFibGUtMy10ZXN0LWNvbmRpdGlvbnMuanBnIn0%3D\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"768\" height=\"94\" src=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-3-test-conditions-768x94.jpg\" class=\"attachment-medium_large size-medium_large wp-image-15191\" alt=\"Table 3 Test Conditions\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Table 3 Test Conditions<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b33c230 elementor-widget elementor-widget-image\" data-id=\"b33c230\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-2-specimen-information.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"tensile-testing-of-cultured-epidermis-table-2-specimen-information\" data-elementor-lightbox-description=\"Table 2 Specimen Information\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTUxOTAsInVybCI6Imh0dHBzOlwvXC9zaGltYWR6dS10ZXN0aW5nLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDlcL3RlbnNpbGUtdGVzdGluZy1vZi1jdWx0dXJlZC1lcGlkZXJtaXMtdGFibGUtMi1zcGVjaW1lbi1pbmZvcm1hdGlvbi5qcGcifQ%3D%3D\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"179\" src=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-2-specimen-information.jpg\" class=\"attachment-large size-large wp-image-15190\" alt=\"Table 2 Specimen Information\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Table 2 Specimen Information<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-413e636 e-grid e-con-full e-con e-child\" data-id=\"413e636\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2206f5f elementor-widget elementor-widget-image\" data-id=\"2206f5f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-fig1-cultured-epidermis.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"tensile-testing-of-cultured-epidermis-fig1-cultured-epidermis\" data-elementor-lightbox-description=\"Fig 1. Cultured Epidermis\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTUyMDYsInVybCI6Imh0dHBzOlwvXC9zaGltYWR6dS10ZXN0aW5nLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDlcL3RlbnNpbGUtdGVzdGluZy1vZi1jdWx0dXJlZC1lcGlkZXJtaXMtZmlnMS1jdWx0dXJlZC1lcGlkZXJtaXMuanBnIn0%3D\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"692\" height=\"408\" src=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-fig1-cultured-epidermis.jpg\" class=\"attachment-medium_large size-medium_large wp-image-15206\" alt=\"Fig 1. Cultured Epidermis\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Fig 1. Cultured Epidermis<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f029c7 elementor-widget elementor-widget-image\" data-id=\"7f029c7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-fig2-picture-of-the-test-Milk-membrane.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"tensile-testing-of-cultured-epidermis-fig2-picture-of-the-test-Milk-membrane\" data-elementor-lightbox-description=\"Fig. 2 Picture of the Test (Milk Membrane)\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTUxODcsInVybCI6Imh0dHBzOlwvXC9zaGltYWR6dS10ZXN0aW5nLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDlcL3RlbnNpbGUtdGVzdGluZy1vZi1jdWx0dXJlZC1lcGlkZXJtaXMtZmlnMi1waWN0dXJlLW9mLXRoZS10ZXN0LU1pbGstbWVtYnJhbmUuanBnIn0%3D\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"557\" src=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-fig2-picture-of-the-test-Milk-membrane-768x557.jpg\" class=\"attachment-medium_large size-medium_large wp-image-15187\" alt=\"Fig. 2 Picture of the Test (Milk Membrane)\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Fig. 2 Picture of the Test (Milk Membrane)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14438ca elementor-widget elementor-widget-text-editor\" data-id=\"14438ca\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Test Results<\/h2>\nFig. 3 shows the load-displacement curves. Table 4\nindicates the maximum load applied to each material and\nthe slope of the linear portion of the curves. The maximum\nload applied to a material indicates the strength of the\nmaterial and therefore the higher the value, the more\nrobust the material is. The slope of the linear portion of the\ncurve indicates compliance and thus the flexibility of the\nspecimens. A clear difference between cultured epidermis\nA and B was confirmed regarding the maximum load\napplied. Although there was some variation among the\nslopes of the linear portion of the curves on the graph, no\nsignificant difference was observed between the cultured\nepidermis specimens.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2e696ce e-grid e-con-full e-con e-child\" data-id=\"2e696ce\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b38999 elementor-widget elementor-widget-image\" data-id=\"5b38999\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-fig3-load-displacement-curves.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"tensile-testing-of-cultured-epidermis-fig3-load--displacement-curves\" data-elementor-lightbox-description=\"Fig. 3 Load - Displacement Curves\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTUxODgsInVybCI6Imh0dHBzOlwvXC9zaGltYWR6dS10ZXN0aW5nLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDlcL3RlbnNpbGUtdGVzdGluZy1vZi1jdWx0dXJlZC1lcGlkZXJtaXMtZmlnMy1sb2FkLWRpc3BsYWNlbWVudC1jdXJ2ZXMuanBnIn0%3D\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"495\" src=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-fig3-load-displacement-curves-768x495.jpg\" class=\"attachment-medium_large size-medium_large wp-image-15188\" alt=\"Fig. 3 Load - Displacement Curves\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Fig. 3 Load - Displacement Curves<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-21447e8 elementor-widget elementor-widget-image\" data-id=\"21447e8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-4-test-results-average-1.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"tensile-testing-of-cultured-epidermis-table-4-test-results-average\" data-elementor-lightbox-description=\"Table 4 Test Results (Average)\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTUyMzMsInVybCI6Imh0dHBzOlwvXC9zaGltYWR6dS10ZXN0aW5nLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDlcL3RlbnNpbGUtdGVzdGluZy1vZi1jdWx0dXJlZC1lcGlkZXJtaXMtdGFibGUtNC10ZXN0LXJlc3VsdHMtYXZlcmFnZS0xLnBuZyJ9\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"178\" src=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis-table-4-test-results-average-1-768x178.png\" class=\"attachment-medium_large size-medium_large wp-image-15233\" alt=\"Table 4 Test Results (Average)\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Table 4 Test Results (Average)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1768880 elementor-widget elementor-widget-text-editor\" data-id=\"1768880\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Conclusion<\/h2>\nIn this research, tensile tests were performed using cultured\nepidermis, which is a regenerative medical product, and\nmilk membrane as an example of a quantitative evaluation\nof a material&#8217;s mechanical properties. We were able to\nperform successful tests and to confirm the difference\nbetween two types of cultured epidermis specimens by\nusing our newly developed tension test fixture for cultured\nepidermis.\nOur evaluation system enables evaluations of the\nmechanical properties of regenerative medical products\nand is suitable for the development and evaluation of\nregenerative medical products.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e491e9 elementor-widget elementor-widget-text-editor\" data-id=\"3e491e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>References<\/h2>\n[1] PMDA (2016), &#8220;Technical Guidance for the Quality of\nRegenerative Medical Products (Human Cell-Processed\nProducts) and Implementation of Non-Clinical and Clinical Tests&#8221;,\nNotification issued by the Ministry of Health, Labour and Welfare\nof Japan\n[2] PMDA (2012), &#8220;Quality and Safety Assurance of Cell-Processed\nMedical and Pharmaceutical Products&#8221;, PFSB Notification No.\n0907002 through 0907006\n[3] PMDA (2013) &#8220;Evaluation Index for Autologous iPS Cell-Derived\nRetinal Pigment Epithelial Cells&#8221;, PFSB\/ELD\/OMDE Notification\nNo. 0529001\n[4] V. Trottier (2008), &#8220;IFATS Collection: Using Human Adipose-\nDerived Stem\/Stromal Cells for the Production of New Skin\nSubstitutes&#8221;, pp. 2713-2723, Vol. 26, Issue 10, October, STEM\nCELLS\n[5] Satsuki Fukushima (2014), &#8220;Developing myocardial regeneration\ntherapy using induced pluripotent stem cells of allogeneic\norigin&#8221;, pp. 199-205, Vol. 21, No. 2, Organ Biology\n[6] N. Nakatsuji (2008), &#8220;HLA-haplotype banking and iPS cells&#8221;, Vol.\n26, No. 7, July, Nature Biotechnology\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f8d1c4 elementor-widget elementor-widget-spacer\" data-id=\"8f8d1c4\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-167ca2b e-flex e-con-boxed e-con e-parent\" data-id=\"167ca2b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2bb8546 elementor-widget elementor-widget-heading\" data-id=\"2bb8546\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Download<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-951c335 downloads-liste elementor-widget elementor-widget-text-editor\" data-id=\"951c335\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li><a href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-testing-of-cultured-epidermis.pdf\" target=\"_blank\" rel=\"noopener\">Application: Tensile Testing of Cultured Epidermis<\/a><\/li>\n<\/ul>\n<br>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a119d2d elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-button\" data-id=\"a119d2d\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/shimadzu-testing.com\/wp-content\/uploads\/2024\/09\/tensile-test-of-plastics-with-automatic-extensometer.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Tensile Test of Plastic with Extensometer (PDF)<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Various research institutes and businesses have been developing regenerative medical products*1 in the recent years in order to facilitate the spread of regenerative medicine. Since quality control is crucial for regenerative medical products&#8230;<\/p>\n","protected":false},"author":5,"featured_media":15206,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[348,335],"tags":[],"class_list":["post-15192","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ez-sx","category-tensile-testing"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tensile Testing of Cultured Epidermis | Regenerative Medicine<\/title>\n<meta name=\"description\" content=\"Explore Shimadzu&#039;s methods for tensile testing of cultured epidermis to assess mechanical strength, ensuring quality control in regenerative medical products.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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